聖路加国際病院

St Luke's International Hospital

眼科

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  • 読み込み中

部長 小沢 洋子

読み込み中...
小沢 洋子
  • 主な経歴

    1992年 慶應義塾大学医学部卒業・眼科学教室入局

    1995年 佐野厚生総合病院眼科 医長

    1997年 慶應義塾大学医学部 眼科学教室 網膜硝子体フェロー

    1998年 東京都済生会中央病院眼科 網膜硝子体フェロー

    2001年 慶應義塾大学医学部生理学教室 国内留学

    2004年 川崎市立川崎病院眼科 副医長

    2005年 慶應義塾大学医学部 眼科学教室 助手

    2008年-2020年3月 慶應義塾大学医学部 眼科学教室 専任講師

    2009年 慶應義塾大学医学部 眼科学教室 網膜細胞生物学研究室 チーフ(兼任)

    2016-17年 Schepens Eye Research Institute (Harvard Medical School) Visiting Scholar (兼任)

    2020年 聖路加国際病院 眼科部長 聖路加国際大学 研究教授

    2020年 慶應義塾大学医学部眼科学教室 特任准教授(兼任)

  • 主な業績

    1.臨床試験
    抗血管内皮増殖因子療法(抗vascular endothelial growth factor療法; 抗VEGF療法)の臨床試験に参加しました。
    加齢黄斑変性に対する試験7件、糖尿病黄斑浮腫に対する試験2件、近視性脈絡膜新生血管に対する試験1件

    2. 取材
    (1) テレビ/ラジオ出演
    2012年12月24日 AMラジオニッポン放送 第38回ラジオチャリティーミュージックソン「中途失明の原因となる病気~iPS細胞の可能性」
    2012年6月1日 NHK 「 ブルーライト」健康への影響は?

    (2) 新聞掲載
    2015年11月号 食品化学新聞社, FOOD Style 21 特集インタビュー. 「視機能とサプリメント」.
    2014年8月5日 東京新聞, 暮らし18 紙上 診察室.「加齢黄斑変性の治療法は」
    2012年5月24日 健康産業流通新聞. 「作用の本質は発症予防」--眼科医の考察- AMDに対するルテインの重要性
    2011年11月6日 日本経済新聞, 健康.「視界がゆがむ加齢黄斑変性」
    2010年8月3日 東京新聞, 生活.「黄斑上膜」

    (3) 刊行物掲載
    2021年4月22日 若々(健康ジャーナル) 株式会社わかさ生活 5月号 特集 目 「生活習慣の変化とともに増加 加齢黄斑変性の予防と治療」
    2019年7月6日 MyAge, 集英社. 2019 夏号Vol. 18, 132-133. 「目のエイジングを遅らせるには 「酸化ストレス」と「慢性炎症」対策を.」
    2019年3月15日 週刊朝日. 第124巻第14号34-37. 「加齢に負けない目ヂカラを極める方法」
    2019年2月21日 日刊ゲンダイ. 「知られざる加齢黄斑変性の深刻さ」
    2019年 週刊朝日MOOK, 23. 「眼科医 外科、内科分野を横断する専門性も魅力」医者と医学部がわかる.
    2018年11月29日 日経メディカル. 「ブルーライトは視力を低下させる? させない?」
    2015年.  参天製薬株式会社, 社内誌ビ・ザ・ビ. 社外に学ぶOPEN YOUR EYES「目を守り抜くために眼科医としてできること」
    2014年5月20日 健康ジャーナル. 「機能性素材探訪 急増するAMDに備え『目』の健康のために」
    2013年3月14日 第163号からだ情報 すこぶる. 中高年の目の病気. 特集 ドクターにお聞きしました「作用の本質は発症予防」.
    2013年3月5日 週刊エコノミスト, 健康アプリ. 加齢黄斑変性
    2012年 I.B HEALTH CARE No.8, 2012. 「加齢黄斑変性」は予防が重要
    2011年 ノバルティス座談会.「加齢黄斑変性Q&A」
    2010年11月 パトス 元気アップ講座.「加齢黄斑変性とルテイン」
    2010年4月15日 Medical News 海外ジャーナルハイライト. 「ルテインに網膜神経保護作用 糖尿病患者の視機能維持に道」

  • 論文業績

    *Corresponding author, First or Equally first author.

    Original Articles

    1. Minami S, Uchida A, Nagai N, Shinoda H, Kurihara T, Ban N, Terasaki H, Takagi H, Tsubota K, Sakamoto T, Ozawa Y*. Shorter axial length is a risk factor for proliferative vitreoreti-nopathy grade C in eyes unmodified by surgical invasion. J Clin Med. 2021, 10(17), 3944.
    2. Guzman NA, Homma K, Osada H, Toda E, Ban N, Nagai N, Negishi K, Tsubota K, Ozawa Y*. Neuroprotective effect of 4-phenylbutyric acid against photo-stress in the retina. Antioxidants. 2021 Jul 10(7), 1147.
    3. Nakamura K, Honda R, Soeda S, Nagai N, Takahashi O, Kadonosono K, Ozawa Y*. Factors associated with achieving intraocular pressure lower than 15 mmHg by Trabectome surgery in primary open-angle glaucoma. Sci Rep. 2021 Jul 12;11(1):14308.
    4. Shinojima A, Ozawa Y*¶, Uchida A, Nagai N, Shinoda H, Kurihara T, Suzuki M, Minami S, Negishi K, Tsubota K. Assessment of Hypofluorescent Foci on Late-Phase Indocyanine Green Angiography in Central Serous Chorioretinopathy. J Clin Med. 2021 May 18;10(10):2178.
    5. Osada H, Toda E, Homma K, Guzman NA, Nagai N, Ogawa M, Negishi K, Arita M, Tsubota K, and Yoko, Ozawa Y*. ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss. Cell Death Dis. 2021 May 7;12(5):458.
    6. Aketa N, Uchino M, Kawashima M, Uchino Y, Yuki K, Ozawa Y*, Sasaki M, Yamagishi K, Sawada N, Tsugane S, Tsubota K, Iso H. Myopia, Corneal Endothelial Cell Density and Morphology in a Japanese Population-Based Cross-Sectional Study: The JPHC-NEXT Eye Study. Sci Rep. 2021 Mar 18;11(1):6366.
    7. Homma K, Toda E, Osada H, Nagai N, Era T, Tsubota K, Okano H, Ozawa Y*. Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium. Redox Biol. 2021. Feb 28;41:101921.
    8. Mori T, Kikuchi T, Koh M, Koda Y, Yamazaki R, Sakurai M, Tomita Y, Ozawa Y, Kohashi S, Abe R, Saburi M, Kato J.Cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation under cytomegalovirus antigenemia-guided active screening. Bone Marrow Transplant. 2020 Dec 12. Online ahead of print.
    9. Nagai N, Kawashima H, Toda E, Homma K, Osada H, Guzman N, Shibata S, Uchiyama Y, Okano H, Tsubota K, Ozawa Y*. Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models. Commun Biol. 2020 Dec 9;3(1):767.
    10. Ozawa Y*. Oxidative stress in the light-exposed retina and its implication in age-related macular degeneration. Redox Biol. 2020 in press
    11. Sato M, Minami S, Nagai N, Suzuki M, Kurihara T, Shinojima A, Sonobe H, Akino K, Ban N, Watanabe K, Uchida A, Shinoda H, Tsubota K, Ozawa Y*. Association between axial length and choroidal thickness in early age-related macular degeneration. PLoS One. 2020 Oct 9;15(10):e0240357.
    12. Akino K, Nagai N, Watanabe K, Ban N, Kurihara T, Uchida A, Shinoda H, Tsubota K, Ozawa Y*. Risk of newly developing visual field defect and neurodegeneration after pars plana vitrectomy for idiopathic epiretinal membrane. Br J Ophthalmol. 2020 Oct 5;bjophthalmol-2020-317478.
    13. Asato T, Nagai N, Suzuki M, Uchida A, Kurihara T, Ban N, Minami S, Shinoda H, Tsubota K, Ozawa Y*. Closure of macular hole secondary to ischemic hemi-central retinal vein occlusion by retinal photocoagulation and topical anti-inflammatory treatment. Lasers in Medical Science. 2020 Aug 21. doi: 10.1007/s10103-020-03133-9. Online ahead of print.
    14. Mushiga Y, Minami S, Uchida A, Nagai N, Suzuki M, Kurihara T, Sonobe H, Ban N, Watanabe K, Shinoda H, Tsubota K, Ozawa Y*. Hyperreflective material in optical coherence tomography images of eyes with myopic choroidal neovascularization may affect visual outcome. J Clin Med. 2020 Jul 27;9(8):E2394.
    15. Minami S, Nagai N, Suzuki M, Uchida A, Shinoda H, Tsubota K, Ozawa Y*. Ocular and Systemic Effects of Antioxidative Supplement Use in Young and Healthy Adults: Real-World Cross-Sectional Data. Antioxidants (Basel). 2020 Jun 3;9(6): E487.
    16. Nagai N, Suzuki M, Uchida A, Kurihara T, Ban N, Minami S, Shinoda H, Tsubota K, Ozawa Y*. The area and number of intraretinal cystoid spaces predict the visual outcome after ranibizumab monotherapy in diabetic macular edema. J Clin Med. 2020 May 8;9(5): E1391.
    17. Nagai N, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H, Watanabe K, Uchida A, Ban N, Tsubota K, Ozawa Y*. Macular pigment optical density and photoreceptor outer segment length as predisease biomarkers for age-related macular degeneration. J Clin Med. 2020 May 5;9(5): E1347.
    18. Suzumura A, Kaneko H, Funahashi Y, Takayama K, Nagaya M, Ito S, Okuno T, Hirakata T, Nonobe N, Kataoka K, Shimizu H, Namba R, Yamada K, Ye F, Ozawa Y, Yokomizo T, Terasaki H. n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Müller BDNF in Diabetic Retinopathy. Diabetes. 2020 Apr;69(4):724-735.
    19. Nagai N, Asato T, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H, Watanabe K, Uchida A, Ban N, Tsubota K, Ozawa Y*. Correlation between macular pigment optical density and neural thickness and volume of the retina. Nutrients. 2020 Mar 25;12(4).
    20. Hanyuda A, Sawada N, Yuki K, Uchino M, Ozawa Y, Sasaki M, Yamagishi K, Iso H, Tsubota K, Tsugane S. Relationships of diabetes and hyperglycaemia with intraocular pressure in a Japanese population: the JPHC-NEXT Eye Study. Sci Rep. 2020 Mar 24;10(1):5355.
    21. Kawashima H, Ozawa Y*, Toda E, Homma K, Osada H, Narimatsu T, Nagai N, Tsubota K. Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator. FASEB J. 2020 Feb 24.
    22. Uchida A, Sasaki M, Motomura K, Yuki K, Kurihara T, Tomita Y, Ozawa Y, Yamagishi K, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H. Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study. Sci Rep. 2020 Jan 21;10(1):779.
    23. Minami S, Shinoda H, Shigeno Y, Nagai N, Kurihara T, Watanabe K, Sonobe H, Takagi H, Tsubota K, Ozawa Y*. Effect of axial length and age on the visual outcome of patients with idiopathic epiretinal membrane after pars plana vitrectomy. Sci Rep. 2019 Dec 13; 9(1):19056.
    24. Ozawa Y*, Shinoda H, Nagai N, Tsubota K. Dynamic changes in neural retinal images during the development of a lamellar macular hole: A case report. Medicine (Baltimore). 2019 Dec; 98(49): e18297.
    25. Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Takagi H, Tsubota K, Ozawa Y*. Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults. Sci Rep. 2019 Dec 2; 9(1):18119.
    26. Okamoto T, Kawashima H, Osada H, Toda E, Homma K, Nagai N, Imai Y, Tsubota K, Ozawa Y*. Dietary Spirulina supplementation protects visual function from photostress by suppressing retinal neurodegeneration in mice. Transl Vis Sci Technol. 2019 Nov 20; 8(6):20.
    27. Suzuki M, Nagai N, Minami S, Kurihara T, Kamoshita M, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y*. Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy. Graefes Arch Clin Exp Ophthalmol. 2020 Jan;258(1):49-56.
    28. Ozawa Y*, Toda E, Kawashima H, Homma K, Osada H, Nagai N, Abe Y, Yasui M, Tsubota K. Aquaporin 4 suppresses neural hyperactivity and synaptic fatigue and fine-tunes neurotransmission to regulate visual function in the mouse retina. Mol Neurobiol. 2019 Dec; 56(12):8124-8135.
    29. Mori K, Kurihara T, Uchino M, Torii H, Kawashima M, Sasaki M, Ozawa Y, Yamagishi K, Iso H, Sawada N, Tsugane S, Yuki K, Tsubota K. High myopia and its associated factors in JPHC-NEXT Eye Study: a cross-sectional observational study. J Clin Med. 2019 Oct 25; 8(11).
    30. Saito S, Tanaka R, Sasaki T, Aoki S, Yasuhara R, Nakayama Y, Nagai T, Sonobe H, Ozawa Y, Kubo A. Subclinical hypopigmentation of the skin and hair in a Japanese patient with Hermansky-Pudlak syndrome type 3. J Dermatol. 2019 Oct 16.
    31. Mimura R, Mori K, Torii H, Nagai N, Suzuki M, Minami S, Ozawa Y, Kurihara T, Tsubota K. Ultra-Widefield Retinal Imaging for Analyzing the Association Between Types of Pathological Myopia and Posterior Staphyloma. J Clin Med. 2019 Sep 20; 8(10).
    32. Nagai N, Suzuki M, Minami S, Kurihara T, Kamoshita M, Sonobe H, Watanabe K, Uchida A, Shinoda H, Tsubota K, Ozawa Y*. Dynamic changes in choroidal conditions during anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy. Sci Rep. 2019 Aug 6; 9(1):11389.
    33. Iyama C, Shigeno Y, Hirano E, Kamoshita M, Nagai N, Suzuki M, Minami S, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y*. QD laser eyewear as a visual field aid in a visual field defect model. Sci Rep. 2019 Jan 30; 9(1):1010.
    34. Hayashi I, Shinoda H, Nagai N, Tsubota K, Ozawa Y*. Retinal inflammation diagnosed as an idiopathic macular hole with multiple recurrences and spontaneous closures: a case report. Medicine (Baltimore). 2019 Jan; 98(4):e14230.
    35. Kawashima H, Nagai N, Shinoda H, Tsubota K, Ozawa Y*. Optic neuropathy causing vertical unilateral hemianopsia after pars plana vitrectomy for a macular hole: a case report. Medicine (Baltimore). 2018 Apr; 97(17):e0321.
    36. Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Kamoshita M, Uchida A, Shinoda H, Takagi H, Sonoda S, Sakamoto T, Tsubota K, Ozawa Y*. Benefits of aflibercept treatment for age-related macular degeneration patients with good best-corrected visual acuity at baseline. Sci Rep. 2018 Jan 8; 8(1):58.
    37. Ban N, Ozawa Y*, Osada H, Jonathan B. Lin, Toda E, Watanabe M, Yuki K, Kubota S, Rajendra S. Apte, Tsubota K. Neuroprotective role of retinal SIRT3 against acute photo-stress. NPJ Aging Mech Dis. 2017 Dec 4; 3:19.
    38. Ozawa Y*, Shigeno Y, Nagai N, Suzuki M, Kurihara T, Minami S, Hirano E, Shinoda H, Kobayashi S, Tsubota K. Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration. BMC Ophthalmol. 2017 Aug 29; 17(1):161.
    39. Osada H, Okamoto T, Kawashima H, Toda E, Miyake S, Nagai N, Kobayashi S, Tsubota K, Ozawa Y*. Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS One. 2017 Jun 1;12(6):e0178627
    40. Nagai N, Ibuki M, Shinoda H, Kameyama K, Tsubota K, Ozawa Y*. Maculopapular rash after intravitreal injection of an anti-vascular endothelial growth factor, aflibercept, for treating age-related macular degeneration: A case report. Medicine (Baltimore). 2017 May; 96(21):e6965.
    41. Sato S, Shinoda H, Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Tomita Y, Iyama C, Minami S, Yuki K, Tsubota K, Ozawa Y*. Predictive factors of better outcomes by monotherapy of an anti-vascular endothelial growth factor drug, ranibizumab, for diabetic macular edema in clinical practice. Medicine (Baltimore). 2017 Apr; 96(16):e6459.
    42. Horie Y, Kitaichi N, Hijioka K, Sonoda KH, Saishin Y, Kezuka T, Goto H, Takeuchi M, Nakamura S, Kimoto T, Shimakawa M, Kita M, Sugita S, Mochizuki M, Hori J, Iwata M, Shoji J, Fukuda M, Kaburaki T, Numaga J, Kawashima H, Fukushima A, Joko T, Takai N, Ozawa Y, Meguro A, Mizuki N, Namba K, Ishida S, Ohno S. Ocular Behçet’s disease is less complicated with allergic disorders. A nationwide survey in Japan. Clin Exp Rheumatol. 2016 Sep-Oct; 34 supple 102 (6):111-114
    43. Fujinami K, Kameya S, Kikuchi S, Ueno S, Kondo M, Hayashi T, Shinoda K, Machida S, Kuniyoshi K, Kawamura Y, Akahori M, Yoshitake K, Katagiri S, Nakanishi A, Sakuramoto H, Ozawa Y, Tsubota K, Yamaki K, Mizota A, Terasaki H, Miyake Y, Iwata T, Tsunoda K. Novel RP1L1 Variants and Genotype-Photoreceptor Microstructural Phenotype Associations in Cohort of Japanese Patients with Occult Macular Dystrophy. Invest Ophthalmol Vis Sci. 2016 Sep; 57 (11):4837-46.
    44. Kamoshita M, Toda E, Osada H, Narimatsu T, Kobayashi S, Tsubota K, Ozawa Y*. Lutein acts via multiple antioxidant pathways in the photo-stressed retina. Sci Rep. 2016 Jul; 22; 6:30226.
    45. Nagai N, Ohta Y, Izumi-Nagai K, Shinoda H, Tsubota K, Ozawa Y*. Sneddon’s syndrome with optic disc macroaneurysm and macular edema successfully treated with subtenon steroid injection. Acta Ophthalmol. 2016 Sep; 94(6):e517-9
    46. Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Minami S, Shinoda H, Tsubota K, Ozawa Y*. Non-responsiveness to intravitreal aflibercept treatment in neovascular age-related macular degeneration: implications of serous pigment epithelial detachment. Sci Rep. 2016 Jul; 11; 6: 29619.
    47. Kamoshita M, Fujinami K, Toda E, Tsubota K, Ozawa Y*. Neuroprotective effect of activated 5'-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation. BMC Neurosci. 2016 Jun; 17:32.
    48. Suzuki M, Nagai N, Shinoda H, Uchida A, Kurihara T, Tomita Y, Kamoshita M, Iyama C, Tsubota K, Ozawa Y*. Distinct responsiveness to intravitreal ranibizumab therapy in polypoidal choroidal vasculopathy with single or multiple polyps. Am J Ophthalmol. 2016 Jun; (166)52-9.
    49. Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, Ozawa Y*. Angiopoietin-like protein 2 is a multistep regulator of inflammatory neovascularization in a murine model of age-related macular degeneration. J Biol Chem. 2016 Apr; 291(14)7373-85.
    50. Tomita Y, Nagai Y, Suzuki M, Shinoda H, Uchida A, Mochimaru H, Izumi-Nagai K, Sasaki M, Tsubota K, Ozawa Y*. Functional Visual Acuity in Age-Related Macular Degeneration. Optom Vis Sci. 2016 Jan; 93(1):70-6.
    51. Okamoto T, Ozawa Y*, Kamoshita M, Osada H, Toda E, Kurihara T, Nagai N, Umezawa K, Tsubota K. The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-KB Axis during Retinal Inflammation. PLoS One. 2016 Jan; 11(1):e0146517.
    52. Ozawa Y*, Koto T, Shinoda H, Tsubota K. Vision loss by central retinal vein occlusion after Kaatsu training: a case report. Medicine (Baltimore). 2015 Sep; 94(36):e1515.
    53. Tomita Y, Kurihara T, Uchida A, Nagai N, Shinoda H, Tsubota K, Ozawa Y*. Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling. Sci Rep. 2015 Sep; 2; 5:13256.
    54. Ozawa Y*, Kawashima M, Inoue S, Inagaki E, Suzuki A, Ooe E, Kobayashi S, Tsubota K. Bilberry extract supplementation for preventing eye fatigue in video display terminal workers. J Nutr health Aging. 2015 May; 19(5):548-54.
    55. Yotsukura-Tsutsui E, Koto T, Tsubota K, Ozawa Y*. Predisposing factors for IOL dislocation treated by pars plana vitrectomy; Involvement of atopic dermatitis. J Cataract Refract Surg. 2015 Apr; 41(4):892-4.
    56. Nagai N, Izumi-Nagai K, Suzuki M, Shinoda H, Koto T, Uchida A, Mochimaru H, Tomita Y, Miyake S, Kobayashi S, Sasaki M, Tsubota K, Ozawa Y*. Association of Macular Pigment Optical Density (MPOD) with serum concentration of oxidized low-density lipoprotein (oxidized LDL) in Healthy Adults. Retina. 2015 Apr; 35(4):820-6.
    57. Ono T, Yuki K, Awano-Tanabe S, Fukagawa K, Shimoyama M, Ozawa Y, Ozeki N, Shiba D, Tsubota K. Driving self-restriction and motor vehicle collision occurrence in glaucoma. Optom Vis Sci. 2015 Mar; 92(3):357-64.
    58. Kamoshita M, Matsumoto Y, Nishimura K, Katono Y, Murata M, Ozawa Y, Shimmura S, Tsubota K. Wickerhamomyces anomalus Fungal Keratitis Responds to Topical Treatment with Antifungal Micafungin. J Infect Chemother. 2015 Feb; 21(2):141-3.
    59. Fujinami K, Jana Zernant, Ravinder K Chana, Genevieve A Wright, Tsunoda K, Ozawa Y, Tsubota K, Anthony G Robson, Graham E Holder, Rando Allikmets, Michel Michaelides, Anthony T Moore. Clinical and Molecular Characteristics of Childhood-onset Stargardt Disease. Ophthalmology. 2015 Feb; 122(2):326-34.
    60. Narimatsu T, Negishi K, Miyake S, Hirasawa M, Kurihara T, Tsubota K, Ozawa Y*. Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo. Exp Eye Res. 2015 Jan 7; 132:48-51.
    61. Ono T, Yuki K, Asaoka R, Kouyama K, Abe T, Tanabe S, Fukagawa K, Uchino M, Shimoyama M, Ozawa Y, Ozeki N, Shiba D, Tsubota K. Glaucomatous Visual Field Defect Severity and the Prevalence of Motor Vehicle Collisions in Japanese: A Hospital/Clinic-Based Cross-Sectional Study. J Ophthalmol. 2015; 2015:497067.
    62. Nagai N, Kubota S, Tsubota K, Ozawa Y*. Resveratrol Prevents the Development of Choroidal Neovascularization by Modulating AMP-activated Protein Kinase in Macrophages and Other Cell Types. J Nutr Biochem. 2014 Nov; 25(11):1218-25.
    63. Okamoto T, Shinoda H, Kurihara T, Nagai N Tsubota K, Ozawa Y*. Intraoperative and fluorescein angiographic findings of a secondary macular hole associated with age-related macular degeneration treated by pars plana vitrectomy. BMC Ophthalmol. 2014 Sep 30; 14:114.
    64. Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Sasaki M, Tsubota K, Ozawa Y*. Predictive factors for non-responders to intravitreal ranibizumab treatment in age-related macular degeneration. Br J Ophthalmol. 2014 Sep; 98(9):1186-91.
    65. Sasaki M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Tien Yin Wong, Ozawa Y*. Early Signs of Exudative Age-related Macular Degeneration in Asians. Optom Vis Sci. 2014 Aug; 91(8):849-53.
    66. Narimatsu T, Ozawa Y*, Miyake S, Kubota S, Yuki K, Nagai N, Tsubota K. Biological effects of blocking blue and other visible light on the mouse retina. Clin Experiment Ophthalmol. 2014 Aug; 42(6):555-63.
    67. Kamoshita M, Ozawa Y*, Kubota S, Miyake S, Tsuda C, Nagai N, Yuki K, Shimmura S, Umezawa K, Tsubota K. AMPK-NF-κB Axis in the Photoreceptor Disorder during Retinal Inflammation. PLoS One. 2014 Jul 21; 9(7):e103013.
    68. Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S. Decreased proteasomal activity causes photoreceptor degeneration in mice. Invest Ophthalmol Vis Sci. 2014 Jul 3; 55(7):4682-90.
    69. Yoshida T, Ozawa Y*, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Mol Brain 2014 Jun 16; 7:45.
    70. Miyake S, Kobayashi S, Tsubota K, Ozawa Y*. Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line. Biochem Biophys Res Commun. 2014 Apr 4; 446(2):535-40.
    71. Narimatsu T, Ozawa Y*, Miyake S, Nagai N, Tsubota K. Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina. Free Radic Biol Med. 2014 Mar 22; 71:176-185.
    72. Sasaki M, Kawashima M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Jie Jin Wang, Ozawa Y*. Association of Serum Lipids with Macular Thickness and Volume in Type 2 Diabetes without Diabetic Macular Edema. Invest Ophthalmol Vis Sci. 2014 Mar 20; 55(3):1749-53.
    73. Uchida A, Shinoda H, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y*. Vitrectomy for myopic foveoschisis with internal limiting membrane peeling and no gas tamponade. Retina. 2014 Mar; 34(3): 455-60.
    74. Uchida A, Miwa M, Shinoda H, Koto T, Nagai N, Mochimaru H, Tomita Y, Sasaki M, Ikeda K, Tsubota K, Ozawa Y*. Association of Maternal Age to Development and Progression of Retinopathy of Prematurity in Infants of Gestational Age under 33 Weeks. J Ophthalmol. 2014; 2014: 187929.
    75. Kudo M, Wada S, Ogawa T, Namiki S, Ozawa Y, Tsubota K, Shinjo A, Suzuki K. Possibility of medical prevention of age-related macular degeneration using confocal micro-imaging system. Int. J. of Nanomanufacturing 2014; 10(4):321-331.
    76. Ban N, Ozawa Y*, Inaba T, Miyake S, Watanabe M, Shinmura K, Tsubota K. Light-dark condition regulates sirtuin mRNA levels in the retina. Exp Gerontol. 2013 Nov; 48(11):1212-7.
    77. Yuki K, Tanabe S, Kouyama K, Fukagawa K, Uchino M, Shimoyama M, Ozeki N, Shiba D, Ozawa Y, Abe T, Tsubota K. The Association between Visual Field Defect Severity and Fear of Falling in Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci. 2013 Nov 21; 54(12):7739-45.
    78. Yuki K, Yoshida T, Seiji M, Tsubota K, Ozawa Y*. Neuroprotective Role of Superoxide Dismutase 1 in Retinal Ganglion Cells and Inner Nuclear layer Cells against N-methyl-D-aspartate-induced cytotoxicity. Exp Eye Res. 2013 Oct; 115: 230-8.
    79. Fujinami K, Zernant J, Chana RK, Wright GA, Tsunoda K, Ozawa Y, Tsubota K, Webster AR, Moore AT, Allikmets R, Michaelides M. ABCA4 Gene Screening by Next-Generation Sequencing in a British Cohort. Invest Ophthalmol Vis Sci. 2013 Oct 11; 54(10):6662-74.
    80. Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T, Watanabe M, Tsubota K. Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders. Exp Gerontol. 2013 Oct; 48(10):1096-100.
    81. Nishi Y, Shinoda H, Uchida A, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y*. Detection of Early Visual Impairment in Patients with Epiretinal Membrane. Acta Ophthalmol. 2013 Aug; 91(5):e353-7.
    82. Yoshikawa N, Noda K, Ozawa Y, Mashima Y, Ishida S. Blockade for Vascular Adsion Protein-1 Suppresses Pathological Neovascularization in Oxygen-Induced Retinopathy. Acta Ophthalmol. 2013 Aug; 91(5):e409-10.
    83. Narimatsu T, Ozawa Y*, Miyake S, Kubota S, Hirasawa M, Nagai N, Shimmura S, Tsubota K. Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice. Invest Ophthalmol Vis Sci. 2013 Jul 8; 54(7):4555-62.
    84. Fujinami K, Tsunoda K, Nakamura N, Kato Y, Noda T, Shinoda K, Tomita K, Hatase T, Usui T, Akahori M, Itabashi T, Iwata T, Ozawa Y, Tsubota K, Miyake Y. Molecular Characteristics of Four Japanese Cases with KCNV2-retinopathy: Report of Novel Disease-causing Variants. Mol Vis. 2013 Jul 20; 19:1580-90.
    85. Yaguchi S, Ogawa Y, Shimmura S, Kawakita T, Hatou S, Satofuka S, Nakamura S, Imada T, Miyashita H, Yoshida S, Yaguchi T, Ozawa Y, Mori T, Tsubota K. Angiotensin II Type 1 Receptor Antagonist Attenuates Lacrimal Gland, Lung, and Liver Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease. PLoS One. 2013 Jun 6; 8(6):e64724.
    86. Yoshikawa N, Noda K, Shinoda H, Uchida A, Ozawa Y, Tsubota K, Mashima Y, Ishida S. Serum vascular adhesion protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes. J Diabetes Complications. 2013 Mar-Apr; 27(2):162-6.
    87. Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A, Ishida S. Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice. J Neurosci. 2013 Dec 4; 33(49):19341-51.
    88. Ozawa Y*, Yuki K, Yamagishi R, Tsubota K, Aihara M. Renin–angiotensin system involvement in the oxidative stress-induced neurodegeneration of cultured retinal ganglion cells. Jpn J Ophthalmol. 2013 Jan; 57(1):126-32.
    89. Uchida A, Shinoda K, Matsumoto C.S, Kawai M, Kawai S, Ohde H, Ozawa Y, Ishida S, Inoue M, Mizota A, Tsubota K. Acute visual field defect following vitrectomy determined to originate from optic nerve by electrophysiological tests. Case Rep Ophthalmol. 2012 Sep; 3(3):396-405.
    90. Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, Imada T, Ozawa Y, Kawakami Y, Ishida S, Tsubota K. Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2012 Aug 13; 53(9):5416-25.
    91. Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S. Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2012 Jun 26; 53(7):4055-62.
    92. Sasaki M, Yuki K, Kurihara T, Miyake S, Noda K, Kobayashi S, Ishida S, Tsubota K, Ozawa Y*. Biological role of lutein in the light-induced retinal degeneration. J Nutr Biochem. 2012 May; 23(5):423-9.
    93. Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T, Kubota Y. The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner. Dev Biol. 2012 Mar 1; 363(1):106-14.
    94. Sasaki M, Shinoda H, Koto T, Uchida A, Tsubota K, Ozawa Y*. Use of micronutrient supplement for preventing advanced Age-related Macular Degeneration in Japan. Arch Ophthalmol. 2012 Feb; 130(2):254-5.
    95. Miyake S, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y*. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism. Lab Invest. 2012 Jan; 92(1):102-9.
    96. Miyake S, Sasaki M, Takahashi N, Tsubota K, Ozawa Y*. Photo-damage mechanisms and anti-apoptotic effect of lutein in the mouse retina. Inflammation and Regeneration. 32(5), 208-212, 2012.
    97. Kurihara T, Ozawa Y, Ishida S, Okano H, Tsubota K. Renin-Angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction. Int J Inflam. 2012; 2012:581695.
    98. Yoshikawa N, Noda K, Ozawa Y, Tsubota K, Mashima Y, Ishida S. Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization. Mol Vis. 2012; 18:593-600.
    99. Oshima CR, Yuki K, Uchida A, Dogru M, Koto T, Ozawa Y, Tsubota K. The Vision Van, a Mobile Eye Clinic, Aids Relief Efforts in Tsunami-stricken Areas. Keio J Med. 2012; 61(1):10-4.
    100. Suzuki M, Ozawa Y*, Kubota S, Hirasawa M, Miyake S, Noda K, Tsubota K, Kadonosono K, Ishida S. Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor. J Neuroinflammation. 2011 Dec 16; 8:176.
    101. Kubota S, Ozawa Y*, Kurihara T, Sasaki M, Yuki K, Miyake S, Noda K, Ishida S, Tsubota K. Roles of AMP-Activated Protein Kinase in Diabetes-Induced Retinal Inflammation. Invest Ophthalmol Vis Sci. 2011 Nov 25; 52(12):9142-8.
    102. Yuki K, Ozawa Y*, Yoshida T, Kurihara T, Hirasawa M, Ozeki N, Shiba D, Noda K, Ishida S, Tsubota K. Retinal ganglion cell loss in superoxide dismutase 1 deficiency. Invest Ophthalmol Vis Sci. 2011 Jun 13; 52(7):4143-50.
    103. Shinoda H, Koto T, Fujiki K, Murakami A, Tsubota K, Ozawa Y*. Clinical findings in a choroideremia patient who underwent vitrectomy for retinal detachment associated with macular hole. Jpn J Ophthalmol. 2011 Mar; 55(2):169-71.
    104. Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci. 2011 Jan 21; 52(1):427-33.
    105. Hirasawa M, Noda K, Noda S, Suzuki M, Ozawa Y, Shinoda K, Inoue M, Ogawa Y, Tsubota K, Ishida S. Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization. Mol Vis. 2011; 17:1222-30.
    106. Kubota S, Kurihara T, Ebinuma M, Kubota M, Yuki K, Sasaki M, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K. Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation. Am J Pathol. 2010 Oct; 177(4):1725-31.
    107. Suzuki M, Noda K, Kubota S, Hirasawa M, Ozawa Y, Tsubota K, Mizuki N, Ishida S. Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis. Mol Vis. 2010 Jul 17; 16:1382-8.
    108. Sasaki M, Ozawa Y*, Kurihara T, Kubota S, Yuki K, Noda K, Kobayashi S, Ishida S, Tsubota K. Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes. Diabetologia. 2010 May; 53(5):971-9.
    109. Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H. von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development. 2010 May; 137(9):1563-71.
    110. Tomita Y, Noda K, Shinoda H, Ozawa Y, Tsubota K, Ishida S. Secondary macular hole formation with presumed evulsion of foveal hard exudates in a patient with diabetic retinopathy. Jpn J Ophthalmol. 54(4):366-8, 2010.
    111. Sugisaka E, Shinoda K, Sano RY, Ishida S, Imamura Y, Ozawa Y, Shinoda H, Suzuki K, Tsubota K, Inoue M. Mechanism of visual sensations experienced during pars plana vitrectomy under retrobulbar anesthesia. Ophthalmologica. 2010; 224(2):103-8.
    112. Kurihara T, Omoto M, Noda K, Ebinuma M, Kubota S, Koizumi H, Yoshida S, Ozawa Y, Shimmura S, Ishida S, Tsubota K. Retinal phototoxicity in a novel murine model of intraocular lens implantation. Mol Vis. 2009 Dec 12; 15:2751-61.
    113. Mochimaru H, Takahashi E, Tsukamoto N, Miyazaki J, Yaguchi T, Koto T, Kurihara T, Noda K, Ozawa Y, Ishimoto T, Kawakami Y, Tanihara H, Saya H, Ishida S, Tsubota K. Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4410-5.
    114. Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, Ishida S. (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation. Diabetes. 2009 Jul; 58(7):1625-33.
    115. Kubota S, Kurihara T, Mochimaru H, Satofuka S, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K. Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3512-9.
    116. Hirasawa M, Noda K, Shinoda H, Ozawa Y, Tsubota K, Ishida S. Secondary macular hole associated with central retinal vein occlusion treated with corticosteroid injection. Jpn J Ophthalmol. 2009 May; 53(3):279-81.
    117. Sasaki M, Ozawa Y, Kurihara T, Noda K, Imamura Y, Kobayashi S, Ishida S, Tsubota K. Neuroprotective effect of an antioxidant, lutein, during retinal inflammation. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1433-9.
    118. Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, Ishida S. (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system. Am J Pathol. 2008 Dec; 173(6):1911-8.
    119. Satofuka S, Imamura Y, Ishida S, Ozawa Y, Tsubota K, Inoue M. Rhegmatogenous retinal detachment associated with primary congenital glaucoma. Int Ophthalmol. 2008 Oct; 28(5):369-71.
    120. Ozawa Y, Nakao K, Kurihara T, Shimazaki T, Shimmura S, Ishida S, Yoshimura A, Tsubota K, Okano H. Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. J Biol Chem. 2008 Sep 5; 283(36):24561-70.
    121. Kurihara T, Ozawa Y, Nagai N, Shinoda K, Noda K, Imamura Y, Tsubota K, Okano H, Oike Y, Ishida S. Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina. Diabetes. 2008 Aug; 57(8):2191-8.
    122. Hashizume K, Hirasawa M, Imamura Y, Noda S, Shimizu T, Shinoda K, Kurihara T, Noda K, Ozawa Y, Ishida S, Miyake Y, Shirasawa T, Tsubota K. Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice. Am J Pathol. 2008 May; 172(5):1325-31.
    123. Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Ohno S, Oike Y, Ishida S. Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin. Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1679-85.
    124. Susaki K, Kaneko J, Yamano Y, Nakamura K, Inami W, Yoshikawa T, Ozawa Y, Shibata S, Matsuzaki O, Okano H, Chiba C. Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors. Exp Eye Res. 2009 Mar; 88(3):347-55.
    125. Shinoda H, Shinoda K, Satofuka S, Imamura Y, Ozawa Y, Ishida S, Inoue M. Visual recovery after vitrectomy for macular hole using 25-gauge instruments. Acta Ophthalmol. 2008 Mar; 86(2):151-5.
    126. Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Umezawa K, Ohno S, Oike Y, Ishida S. Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2555-62.
    127. Mochimaru H, Nagai N, Hasegawa G, Kudo-Saito C, Yaguchi T, Usui Y, Kurihara T, Koto T, Satofuka S, Shinoda H, Ozawa Y, Tsubota K, Kawakami Y, Ishida S. Suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2. Invest Ophthalmol Vis Sci. 2007 Oct; 48 (10):4795-801.
    128. Koto T, Nagai N, Mochimaru H, Kurihara T, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Oike Y, Ishida S. Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):4328-34.
    129. Nagai N, Izumi-Nagai K, Oike Y, Koto T, Satofuka S, Ozawa Y, Yamashiro K, Inoue M, Tsubota K, Umezawa K, Ishida S. Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream NF-kB pathway. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):4342-50.
    130. Sugisaka E, Shinoda K, Ishida S, Imamura Y, Ozawa Y, Shinoda H, Suzuki K, Tsubota K, Inoue M. Patients' descriptions of visual sensations during pars plana vitrectomy under retrobulbar anesthesia. Am J Ophthalmol. 2007 Aug; 144(2):245-51.
    131. Izumi-Nagai K, Nagai N, Ozawa Y, Mihara M, Ohsugi Y, Kurihara T, Koto T, Satofuka S, Inoue M, Tsubota K, Okano H, Oike Y, Ishida S. Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol. 2007 Jun; 170(6):2149-58.
    132. Nagai N, Oike Y, Izumi-Nagai K, Koto T, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Ishida S. Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: Minimal role of bradykinin. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2321-6.
    133. Ozawa Y, Nakao K, Shimazaki T, Shimmura S, Kurihara T, Ishida S, Yoshimura A, Tsubota K, Okano H. SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. Dev Biol. 2007 Mar 15; 303(2):591-600.
    134. Satofuka S, Ichihara A, Nagai N, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Itoh H, Oike Y, Ishida S. Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):422-9.
    135. Kurihara T, Ozawa Y, Shinoda K, Nagai N, Inoue M, Oike Y, Tsubota K, Ishida S, Okano H. Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5545-52. Equally Contributed
    136. Nagai N, Oike Y, Izumi-Nagai K, Urano T, Kubota Y, Noda K, Ozawa Y, Inoue M, Tsubota K, Suda T, Ishida S. Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization. Arterioscler Thromb Vasc Biol. 2006 Oct; 26(10):2252-9.
    137. Sugisaka E, Shinoda K, Ishida S, Imamura Y, Ozawa Y, Nakajima T, Shinoda H, Suzuki K, Kawaguchi N, Inoue M. Visual Sensations during Vitrectomy. Ophthalmology. 2006 Oct; 113(10):1886.e1-2.
    138. Satofuka S, Ichihara A, Nagai N, Yamashiro K, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Suzuki F, Oike Y, Ishida S. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2686-92.
    139. Nagai N, Oike Y, Noda K, Urano T, Kubota Y, Ozawa Y, Shinoda H, Koto T, Shinoda K, Inoue M, Tsubota K, Yamashiro K, Suda T, Ishida S. Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor. Invest Ophthalmol Vis Sci. 2005 Aug; 46(8):2925-31.
    140. Ozawa Y, Nakao K, Shimazaki T, Takeda J, Akira S, Ishihara K, Hirano T, Oguchi Y, Okano H. Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Mol Cell Neurosci. 2004 26(2): 258-270.
    141. Shinoda K, O'hira A, Ishida S, Hoshide M, Ogawa LS, Ozawa Y, Nagasaki K, Inoue M, Katsura H. Posterior synechia of the iris after combined pars plana vitrectomy, phacoemulsification, and intraocular lens implantation. Jpn J Ophthalmol. 2001 45(3):276-80.
    142. Mashima Y, Shinoda K, Ishida S, Ozawa Y, Kudoh J, Iwata T, Oguchi Y, Shimizu N. Identification of four novel mutations of the XLRS1 gene in Japanese patients with X-linked juvenile retinoschisis. Mutation in brief no. 234. Online. Hum Mutat. 1999 13(4):338.

    Reviews

    1. Ozawa Y*, Kamoshita M, Narimatsu T, Ban N, Toda E, Okamoto T, Yuki K, Miyake S, Tsubota K. Neuroinflammation and Neurodegenerative Disorders of the Retina. Endocrinology & Metabolic Syndrome. 2013 May 22; 2:111.
    2. Ozawa Y*, Suzuki M, Niikura N, Kamoshita M, Nagai N, Tsubota K. Neuroprotective Role of VEGF Induced in Response to Photodynamic Therapy. Adv Neuroimmune Biol. 2013 Volume 4 (3):161-165.
    3. Ozawa Y*, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K. Neuroprotective Effects of Lutein in the Retina. Current Pharmaceutical Design. 2012; 18(1):51-6.
    4. Ozawa Y*, Kurihara T, Tsubota K, Okano H. Regulation of posttranscriptional modification as a possible therapeutic approach for retinal neuroprotection. J Ophthalmol. 2011; 2011:506137.
    5. Ozawa Y*, Kurihara T, Sasaki M, Ban N, Yuki K, Kubota S, Tsubota K. Neural degeneration in the retina of the streptozotocin (STZ)-induced type 1 diabetes model. Exp Diabetes Res. 2011; 2011:108328.
    6. Ozawa Y*, Kubota S, Narimatsu T, Yuki K, Koto T, Sasaki M, Tsubota K. Retinal aging and sirtuins. Ophthalmic Res. 2010; 44(3):199-203.
    7. Ozawa Y*, Ishida S, Tsubota K. Age-related macular degeneration (AMD); From pathogenesis and approved therapies to proposed treatments for prevention. Anti-Aging Medicine. 5 (8), 2008.

    Book Chapters

    1. Ozawa Y*. Oxidative Stress in the RPE and Its Contribution to AMD Pathogenesis: Implication of Light Exposure. Springer Japan. Neuroprtection and Neuroreguration for Retinal Diseases. 2014 239-253 (book)
    2. Ozawa Y*, Sasaki M. Lutein and Oxidative Stress-Mediated Retinal Neurodegeneration in Diabetes. PREEDY Diabetes. 2013, 223-228. (book)
    3. Ozawa Y*, Tsubota K, Okano H. Angiogenesis in Response to Hypoxia. Encyclopedia of the Eye (4-volume Set) VISI: 00122.2010/06. (book)